Immunology of the Chlamydiales

Basic immunology
       Mucosal immunology
       Antigen processing
       Role of cytotoxic T cells

Immunopathology
       Immunopathology
       Inflammation & repair
       Repeated infection
       Cytokine responses
       Virulence
       Apoptosis
       & Heat shock proteins
       Heat shock proteins & CMI
       Role of host genotype

Determinants of protection & pathology  
      Introduction
      Contemporary immunological paradigms
      Immunological parameters controlling chlamydiae
      Anti chlamydial immune effectors
      Protection versus pathology
     Immunoregulation
     Protective antigens
     Cytokine and chemokine factors
     Costimulatory factors
     Antigen targeting
     Antigen delivery
     Vectors and adjuvants
     Bacterial vectors
     Cellular processing and delivery
     FcR mediated delivery of antigen
     Future perspectives
     Immunology review references

  Biology Index
  Main index

Introduction
Importance of scarring and fibrosis
The role of repeated infection
Epithelial response to chlamydial infection
Relative virulence of C. trachomatis
Chlamydial regulation of apoptosis
Chlamydial heat shock proteins
Role of CMI responses: a re-evaluation
Host genetic factors in chlamydial disease

Oct 2002 review by Joseph Igietseme and Carolyn Black, CDC, Atlanta. [17 files]
Introduction: Why its important. Objectives of the review. 
Evidence for protective immunity
Key role of the TH1 system
Role of interferon gamma, antibody and ADCC
Pathology may be associated with a suboptimal Th1 response
Factors influencing the induction of protection
MOMP, POMP, PorB
IL-10 knock out mice are highly resistant
ICAM-1 is important
Targeting for effective mucosal immunity
Advantages and disadvantages of subunit vaccines
DNA vaccines. Virus vectors
Bacterial delivery systems
Processing by dendritic cells
Fc receptor-mediated delivery
Vaccines remain the best hope for long term protection
Hyperlinked immunology references

Index
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