[Biology
section 45 files excluding evolution]
Ultrastructure of the infectious elementary body (EB)
The intracellular replicating form, the reticulate body (RB)
The developmental cycle
EUO, Hc1, codon usage, transcriptional regulation, environmental responses
Hc1-DNA interactions and MEP isoprenoid pathway
Presentation by Peter Timms & Sarah Mathews (32 figures)
Continued presentation by Peter Timms & Sarah Mathews (40 figures)
Chlamydial attachment to the host; GAG
Presentation by Wyrick, Raulston & Davis
Clathrin dependent and independent endocytosis
Release from host cells
How chlamydiae intercept cell membranes
The Inc proteins
Presentation by Marci Scidmore
Interacting with the host cytoplasm
Presentation by Dan Rockey
MOMP, B cell epitopes, VS 1, 2, 4 and serological classification
Inter and intra-genic recombination in ompA. Polymorphisms.
VS3 is important
Di-carboxylate specific porin
OmcA & OmcB. Model for the chlamydial outer membrane complex
PMPs
Macrophage infectivity potentiator
Surface exposed outer envelope protein of unknown function
Penicillin binding; glycopeptide and LPS biosynthesis
LPS structure, endotoxic activity, cytokines, toll receptors
Introduction to genomics and proteomics
The chlamydial genome
Unexpected findings from genomic sequencing
Chlamydial genes and chloroplast evolution
Chlamydiae are reasonably energy self-sufficient
Chlamydial peptidoglycan synthesis
Chlamydial plasmids
Chlamydophila and related bacteriophages Ian Clarke
Twice the genome of the chlamydiaceae & a conjugation system!
What do we mean by persistent infection?
Relationship of persistence to incomplete development
Interferons, persistence, role in chlamydial organotropism
Evidence from experimental animal studies
Case reports
The clinical significance of persistent infection
The mucosal immune system; sIgA Tina Johansson & Nils Lycke
Chlamydial antigen processing by dendritic cells
CD8+ T cells and Cap1
Introduction
Importance of scarring and fibrosis
The role of repeated infection
Epithelial response to chlamydial infection
Relative virulence of C. trachomatis
Chlamydial regulation of apoptosis
Chlamydial Heat shock proteins
Karunakaran / Brunham presentation: Molecular biology of GroEL -ES
Role of CMI responses: a re-evaluation
Host genetic factors in chlamydial disease
Oct 2002 review by Joseph Igietseme and Carolyn Black, CDC,
Atlanta [17 files].
Introduction: Why its important. Objectives of the review.
Evidence for protective immunity
Key role of the TH1 system
Role of interferon gamma, antibody and ADCC
Pathology may be associated with a suboptimal Th1 response
Factors influencing the induction of protection
MOMP, POMP, PorB
IL-10 knock out mice are highly resistant
ICAM-1 is important
Targeting for effective mucosal immunity
Advantages and disadvantages of subunit vaccines
DNA vaccines. Virus vectors
Bacterial delivery systems
Processing by dendritic cells
Fc receptor-mediated delivery
Vaccines remain the best hope for long term protection
Hyperlinked immunology references
Review by Jim Moulder
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